Weekly Spotlight - 09.01.25

Isatuximab Safety in Multiple Myeloma

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Isatuximab, a therapy for multiple myeloma, showed some adverse effects like neutropenia and thrombocytopenia in trials. Despite this, it remains generally safe and manageable. Future studies should focus on long-term safety. This research offers hope and reassurance for patients considering isatuximab treatment.


Belantamab mafodotin is a hopeful treatment for multiple myeloma. It's an antibody-drug conjugate aimed at relapsed cases. Ongoing studies explore its use with other therapies. This innovation marks progress in treatment options, offering potential relief and renewed hope for patients and their families.


Real-world evidence shows ciltacabtagene autoleucel, a CAR T-cell therapy, is effective for relapsed multiple myeloma. Patients' real-world experiences align closely with clinical trials, offering hope and reassurance for many. This breakthrough supports the effectiveness of this treatment, providing a promising future for those affected.

The CARTITUDE-4 trial shows lenalidomide-refractory multiple myeloma patients face higher infection risks with ciltacabtagene autoleucel. Early infection monitoring and prophylaxis are essential. The report supports improvements in patient care, highlighting the importance of vigilance and proper management to ensure better outcomes for these vulnerable patients.

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Health Spotlight’s Multiple Myeloma is a Contentive publication in the Healthcare division