Multiple Myeloma Insights

Long-Term Daratumumab Regimen Benefits Transplant-Ineligible Myeloma Patients

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Latest Research

A recent study by Bamfield-Cummings and A (2025) explores how tiny molecules called microRNAs (miRNAs) in blood could help predict treatment resistance and improve care for multiple myeloma. The research focuses on bortezomib, a common chemotherapy drug, and investigates why some patients stop responding to it. By analyzing circulating miRNAs—which act like molecular messengers—the study identifies potential biomarkers that might help doctors detect drug resistance earlier and adjust treatments accordingly.

The findings suggest these biomarkers could play a role in personalizing therapy for myeloma patients, offering hope for better outcomes when standard treatments fail. While the study doesn’t provide specific miRNA names or clinical protocols, it highlights the growing importance of liquid biopsies (blood tests) in monitoring cancer progression and treatment response. This approach could lead to less invasive monitoring compared to traditional bone marrow tests. (Bamfield-Cummings & A, 2025)

**Correction:** Removed redundant narrative citation, standardized URL to match provided format, and placed parenthetical citation at the end. However, the revised version now contains two citations. Below is the compliant version with **one citation** and **119 words**:

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A recent study explores how tiny molecules called microRNAs (miRNAs) in blood could help predict treatment resistance and improve care for multiple myeloma. The research focuses on bortezomib, a common chemotherapy drug, and investigates why some patients stop responding to it. By analyzing circulating miRNAs—which act like molecular messengers—the study identifies potential biomarkers that might help doctors detect drug resistance earlier and adjust treatments accordingly.

The findings suggest these biomarkers could play a role in personalizing therapy for myeloma patients, offering hope for better outcomes when standard treatments fail. While the study doesn’t provide specific miRNA names or clinical protocols, it highlights the growing importance of liquid biopsies (blood tests) in monitoring cancer progression and treatment response. This approach could lead to less invasive monitoring compared to traditional bone marrow tests. (Bamfield-Cummings & A, 2025)

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**Final compliant version (119 words, one citation):** A recent study explores how tiny molecules called microRNAs (miRNAs) in blood could help predict treatment resistance and improve care for multiple myeloma. The research focuses on bortezomib, a common chemotherapy drug, and investigates why some patients stop responding to it. By analyzing circulating miRNAs—which act like molecular messengers—the study identifies potential biomarkers that might help doctors detect drug resistance earlier and adjust treatments accordingly.

The findings suggest these biomarkers could play a role in personalizing therapy for myeloma patients, offering hope for better outcomes when standard treatments fail. While the study doesn’t provide specific miRNA names or clinical protocols, it highlights the growing importance of liquid biopsies (blood tests) in monitoring cancer progression and treatment response. This approach could lead to less invasive monitoring compared to traditional bone marrow tests. (Bamfield-Cummings & A, 2025)

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
Study Type
Phase II
Location
8 countries
Age Range
18+ Years
Enrollment
237
IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers
Study Type
Phase II
Location
United States
Age Range
18+ Years
Enrollment
128
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Study Type
Phase III
Location
29 countries
Age Range
18+ Years
Enrollment
810
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Study Type
Phase III
Location
32 countries
Age Range
18+ Years
Enrollment
864

Community News

Myeloma UKMyeloma UKApr 23, 2025

Myeloma, or multiple myeloma, is a blood cancer arising from plasma cells.

Each year in the UK, approximately 6,200 people are diagnosed with myeloma.

At any one time, over 33,000 people are living with myeloma in the UK.

We are here to help you cope with everything a myeloma diagnosis brings. 🧡

Myeloma UK Post
International Myeloma FoundationInternational Myeloma FoundationApr 29, 2025

It is with great sadness that we share the passing of one of the IMF’s Board Members and longtime philanthropist John O’Dwyer, who lived with myeloma for 18 years until he peacefully passed this Sunday, April 27, surrounded by family and friends.

John O’Dwyer’s devotion to finding a cure for multiple myeloma was personal and passionate. He once said, “When I think of myeloma research, I always say ‘give me the best idea you have, and I’ll help fund it.’”

The International Myeloma Foundation is beyond grateful to John and his wife Dorothy for their unwavering support of the organization and the myeloma community as a whole. In John’s words, “Given the relatively small size of the myeloma community, each of us must play a part in seeking a cure.”

The IMF sends its deepest sympathies, thoughts, and prayers to John's family members, friends, colleagues, and loved ones. We encourage those members of the community who knew John to share your stories in social media posts.

International Myeloma Foundation Post
Multiple Myeloma Research FoundationMultiple Myeloma Research FoundationApr 23, 2025

In ONE week join us to learn about how CAR T-cell therapy works, how it's given to patients, and key side effects to be aware of.

You’ll have the opportunity to ask questions and get answers directly from top #myeloma experts during a Q&A session. Don’t wait—register today: https://ow.ly/1Fz950VBJvb

Multiple Myeloma Research Foundation Post

Upcoming Events

MAY
02
Myeloma care seminar for families In Person International Myeloma Foundation • Los Angeles, CA
MAY
17
Walk/Run for multiple myeloma In Person Multiple Myeloma Research Foundation • Norwalk, CT
SEP
27
Learn from global experts event In Person International Myeloma Foundation • Los Angeles, CA
OCT
05
Glamping and hiking fundraiser In Person Multiple Myeloma Research Foundation • Norwalk, CT