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Cilta-cel Achieves Deep MRD Negativity in MM Patients

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In a recent study highlighted by Targeted Oncology News (2025), the therapy ciltacabtagene autoleucel showed promising results for patients with multiple myeloma who did not respond to lenalidomide, a commonly used treatment. The therapy improved the rate at which patients achieved minimal residual disease negativity, meaning there were very few cancer cells left in the body after treatment. This is significant because such a status is associated with better outcomes. Furthermore, the study found that responses to ciltacabtagene autoleucel were sustained over time, suggesting that the benefits of the treatment are long-lasting. These findings could represent a substantial step forward in the treatment of multiple myeloma, particularly for those who have not had success with standard care options.

Community News

Myeloma UKMyeloma UKFeb 15, 2025

Cathy Bell and her family raised funds for Myeloma UK by organising a walk in memory of her husband, Allen. The walk was a great success, with 20 family and friends – including dogs and children – all taking part. They raised a fantastic £2,038!

Cathy and Allen’s niece, Katie, came up with the idea to do the sponsored walk and set up the fundraiser. Some of the family couldn’t join the walk at Seahouses with the rest of the group, so they did the walk in Newcastle around where Allen grew up.

We spoke to Cathy about the walk and why it was important to her to raise funds in Allen’s memory: https://www.myeloma.org.uk/news/in-memory-of-allen-bell/

Myeloma UK Post
International Myeloma FoundationInternational Myeloma FoundationFeb 13, 2025

Unfortunately, we know that almost every patient with multiple myeloma will have a relapse, meaning their disease will come back after it's initially treated. Dr. Joe Mikhael, Chief Medical Officer of the International Myeloma Foundation, breaks down insights on early relapse at 2024 ASH meeting. #ASH24#IMFASH24

HealthTree for Multiple MyelomaHealthTree for Multiple MyelomaFeb 14, 2025

Steroids like dexamethasone play a key role in multiple myeloma treatment, but their side effects can be tough to manage. Researchers are exploring ways to reduce steroid doses while keeping treatments effective! 📉✨ Could lowering dexamethasone improve quality of life for myeloma patients? 🤔💭 Read more: https://buff.ly/4b5pPYz

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